Integrated approach to the study of hematological diseases and the immune system /
Medicine - Immunology and Allergology

Autonomic nervous system study

• Noninvasive systems of autonomic nervous system study applied to different diseases with participation in clinical trials.
• Evaluation of cardiovascular autonomic control for diagnosis and follow-up of patients with various diseases such as syncope and primary and secondary dysautonomias and for cardiovascular risk profiling in patients with chronic diseases.
• Application of non-invasive neuromodulation techniques of the autonomic nervous system for the treatment of dysautonomia, inflammation, and depressive symptoms in different cohorts of patients.

Systemic autoimmune diseases

• Development of predictive models for identifying patients at risk for complications related to the underlying disease.
• Single-center and multicenter clinical trials to identify risk factors, progression and response to therapy of systemic autoimmune diseases.
• Translational studies, particularly "Omics" analyses including gene expression, proteomics, microbiomics and metabolomics of systemic autoimmune diseases to identify risk factors, progression and response to therapy.
• Cellular models of immune-mediated diseases.
• Participation in national and international clinical trials

Syncope

• Risk stratification of patients with syncope in the emergency room
• Diagnostic yield of different methods for the study of patients with syncope
• Insight into the pathophysiological mechanisms related to syncope

Allergies

• Identification of new allergens and association between pollen allergy and Oral Allergy Syndrome, the main manifestation of food allergy in adults.
• Study of etiopathogenetic mechanisms and new therapies of chronic urticaria (the Center contributes to the drafting of Italian guidelines), allergic asthma, and drug allergy.
• Clinical, epidemiology and therapy of hymenoptera venom allergy (the Center contributes to the drafting of Italian guidelines and participates in international multicenter studies).

Other research programs
Clinical methodology: critical analysis of the scientific literature, diagnostic, prognostic and therapeutic meta-analysis and in-depth study of the tools used in the diagnostic pathway and to establish prognosis.